SIMPLIFIED WARFARIN DOSE–RESPONSE PHARMACODYNAMIC MODELS
نویسندگان
چکیده
منابع مشابه
Parameter Identifiability of Fundamental Pharmacodynamic Models
Issues of parameter identifiability of routinely used pharmacodynamics models are considered in this paper. The structural identifiability of 16 commonly applied pharmacodynamic model structures was analyzed analytically, using the input-output approach. Both fixed-effects versions (non-population, no between-subject variability) and mixed-effects versions (population, including between-subject...
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Pharmacodynamics is the study of the time course of pharmacological effects of drugs. The field of pharmacodynamic modeling has made many advances, due in part to the relatively recent development of basic and extended mechanism-based models. The purpose of this article is to describe the classic as well as contemporary approaches, with an emphasis on pertinent equations and salient model featu...
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BACKGROUND Vitamin K epoxide reductase subunit 1 (VKORC1) is the molecular target of coumarin anticoagulants and mutations in VKORC1 have been identified previously in individuals who required high warfarin doses. OBJECTIVE Detailed characterization of the relationship between variation in VKORC1 and the warfarin resistance phenotype. PATIENTS AND METHODS Serum warfarin concentration and co...
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AIM The aim of the study was to examine the pharmacokinetic and pharmacodynamic profiles of single doses of warfarin (25 mg) following administration alone, and in combination with multiple doses of donepezil HCl (10 mg day(-1)) in healthy volunteers. METHODS This was an open-label, two-period crossover study in 12 healthy male volunteers, aged 18-55 years, who were randomized to one of the f...
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OBJECTIVES The aim of this study was to systematically review data regarding pharmacokinetic (PK)-pharmacodynamic (PD) parameters from randomized controlled trials relating to interactions between herbal medicines and warfarin. METHODS Three electronic databases were searched to identify relevant trials. Two reviewers independently performed the study selection and data extraction. The risk o...
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ژورنال
عنوان ژورنال: Biomedical Engineering: Applications, Basis and Communications
سال: 2015
ISSN: 1016-2372,1793-7132
DOI: 10.4015/s1016237215500015